Practical Electrochemical Hydroxynitration and Chloronitration Bifunctionalization of Alkenes with NaNO2
Year: 2025
Type: article
Abstract: We herein developed a novel method for generating nitryl free radicals using sodium nitrite for the first time under electrocatalytic conditions. A series of vicinal hydroxynitro or chloronitro compounds was generated in good yields. This methodology features a simple reaction setup, mild reaction conditions, and cheap electrodes and shows excellent functional group tolerance and broad substrate scope, enabling efficient gram-scale reactions with good to excellent yields. Besides, the electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) results provided deeper insights into the reaction mechanism. Further extensions of the method have also confirmed the practicality of the strategy developed.
Source: Chemistry - A European Journal
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4409493860