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Integrating Insulin Resistance and Coronary Artery Disease Severity: Will Triglyceride-Glucose Index Be the Easiest Way?

Year: 2025

Type: article

Abstract: Insulin resistance (IR) is a complex metabolic abnormality associated with genetic and environmental factors, which begins with low glucose metabolism in tissues, particularly in muscle, liver, and adipocytes, with consequent stimulation of pancreatic beta cells to increase insulin production and release.– Accumulation of lipids in a variety of tissues, including muscle, liver, and pancreas, contributes to this process in a phenomenon known as “lipotoxicity.” As IR increases, it stimulates hyperinsulinemia, and this negative cycle perpetuates a metabolic disorder that is [...]

Source: International Journal of Cardiovascular Sciences

DOI: 10.36660/ijcs.20240215

Authors: Frederico Toledo Campo Dall’Orto, Flávia Bittar Brito Arantes, Remo H. M. Furtado, Pedro G. M. de Barros e Silva

Institutions: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Coração - HCFMUSP

Language: English

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409496391