Work

Electroreductive Intramolecular Heck‐Type Cyclization for the Synthesis of Benzofused Oxygenated Heterocycles

Year: 2025

Type: article

Abstract: Conventional synthetic routes to benzofused oxygenated heterocycles, such as dihydrobenzofuran, chromane, and isochromane derivatives, often involve complex synthetic conditions, high costs, and environmental concerns. The key to addressing this challenge lies in achieving transition‐metal‐free C(sp2)I bond cleavage to enable intramolecular radical cyclization. Inspired by electroreductive strategies, a convenient, transition‐metal‐free electroreductive tandem reaction is developed for synthesizing dihydrobenzofuran, chromane, and isochromane derivatives. Comprehensive evaluation demonstrates that this approach not only simplifies synthetic conditions but also suppresses competing hydrogenation and halogenation pathways at the exocyclic carbon radical center.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500222

Authors: Yan Yu, Xin Wang, Yicheng Zhang, Kuai Wang, Ling‐Guo Meng

Institution: Huaibei Normal University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Huaibei Normal University

Awards: G2526702719, G2827183401, G3471042327, G3811440078