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Relationship between vitamin B6 intake and thyroid function in US adults: NHANES 2007–2012 results

Year: 2025

Type: article

Abstract: BACKGROUND: Existing studies have focused on the relationship between vitamin B6 and thyroid disease. However, there is a lack of large cross-sectional studies reporting on the relationship between vitamin B6 and thyroid function. Therefore, the present study aimed to assess the association between vitamin B6 intake and thyroid function in a population of US adults aged 20 years and older, using data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012. METHODS: Demographic, dietary, thyroid function, and relevant data from NHANES 2007-2012 were collected. The relationship between vitamin B6 intake and thyroid function was analysed using weighted multiple regression and restricted cubic spline analysis, including subgroup and interaction analysis. RESULTS: The study included 6954 participants with a weighted mean age of 47.39 ± 16.60 years, mean vitamin B6 intake of 2.07 ± 1.15 mg, and mean TT4 level of 7.88 ± 1.61 μg/dL. A statistically significant negative correlation was noted between vitamin B6 intake and TT4 levels (β = -0.05, 95% CI = -0.10 to 0.00, P = 0.033). In addition to this, subgroup analyses we found: In the gender subgroup, a significant negative correlation was found between vitamin B6 intake and TT4 levels in the male population (β = -0.06, 95% CI = -0.11 to -0.01, P = 0.028); in the age subgroup, a significant negative correlation was found between vitamin B6 intake and TT4 levels in older people aged 60-80 years (β = -0. 13, 95% CI = -0.23 to -0.04, P = 0.008); in the BMI subgroup, we found a significant negative correlation between vitamin B6 intake and TT4 levels in overweight people (BMI: 25-29.9 kg/m2) (β = -0.13, 95% CI = -0.20 to -0.06, P < 0. 001); in the iodine content subgroup, we found a significant negative correlation between vitamin B6 intake and TT4 levels in people with a normal iodine intake (100-299 ug/L) (β = -0.07, 95% CI = -0.13 to -0.01, P = 0.021). Finally, in the subgroups of gender, age, BMI, and iodine content, no interaction was found. CONCLUSIONS: To summarise, we believe that vitamin B6 may reduce serum TT4 levels by inhibiting inflammation.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0321688

Authors: Lei Li, Jiangbo Wang, Jianping Chen

Institution: First Affiliated Hospital of Wannan Medical College

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382