Work

Association between conicity index and gallstone disease: A cross-sectional study from NHANES 2017–2020

Year: 2025

Type: article

Abstract: The conicity index (C-index) is recognized for its association with various diseases. However, the relationship between C-index and gallstone disease (GSD) has not been explored. This study aims to investigate the potential relationship between C-index and GSD prevalence. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to 2020, we analyzed the association between C-index and GSD through survey-weighted multivariate logistic regression and restricted cubic spline regression. Receiver operating characteristic (ROC) curve analysis was utilized to compare the predictive performance of C-index, body mass index (BMI), and waist-to-hip ratio (WHR). The study encompassed 3626 participants and revealed a significant positive relationship between C-index and GSD. In the fully adjusted model, each standard deviation increase in C-index was associated with 30 % rise in the odds of GSD prevalence (OR = 1.30; 95 % CI, 1.06 to 1.59; p = 0.036). The restricted cubic spline analysis found no significant nonlinear relationships between C-index and GSD ( p -nonlinear = 0.213). C-index demonstrated superior predictive power for GSD when compared to WHR ( p < 0.001), and was comparable to BMI ( p = 0.483). This research establishes a strong positive association between C-index and GSD prevalence, suggesting that C-index could serve as a valuable clinical marker for the early detection of gallstones. • A linear positive association exists between conicity index and gallstone disease. • Conicity index outperforms wasit-to-hip ratio in predicting gallstone disease. • Conicity index may be an indicator for early gallstone disease detection.

Source: Preventive Medicine Reports

DOI: 10.1016/j.pmedr.2025.103073

Authors: Jie Wang, Songsheng Zhou, Na He, Yi Cao, Haibiao Wang

Institution: Ningbo Medical Center Lihuili Hospital

Language: English

Topic: Gallbladder and Bile Duct Disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610