Histopathological changes in the trabecular meshwork in primary congenital glaucoma
Year: 2025
Type: article
Study design: Case Report
Abstract: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using hematological and eosin staining. The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region. Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.
Author: Aparna Rao
Institution: L V Prasad Eye Institute
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,590
OpenAlex ID: W4409499702