Pulsed light epithelium-off accelerated corneal collagen crosslinking with 30mW/cm2 irradiance and 7.2 J/cm2 radiant exposure: 2-year results
Year: 2025
Type: article
Abstract: Purpose To evaluate the 2-year outcomes of pulsed light epithelium-off accelerated corneal collagen crosslinking (aCXL) using 30 mW/cm 2 for 8 min (7.2 J/cm 2 ) for the treatment of progressive keratoconus. Methods A total of 23 eyes of 18 patients with progressive keratoconus, that were treated with epithelium-off pulsed light aCXL (30 mW/cm 2 , 8 min) were included in this retrospective study. Tomographic measurements and corrected distance visual acuity (CDVA) were analyzed at the baseline visit (before the aCXL treatment), and at 3-, 12- and 24-months visit. Results The two-year results demonstrated a stable anterior flat keratometry (K1), steep keratometry (K2) and mean keratometry (K mean ) of the anterior and posterior cornea with no significant changes at 3, 12 and 24 months postoperatively, compared to the baseline visit ( p > 0.05). Maximal anterior keratometry (K max ) stabilized from 60.18 ± 6.32 D at baseline to 60.04 ± 7.36 D at 24 months post-aCXL ( p = 0.88). The keratoconus indices and astigmatism of the front and back surface of the cornea also showed stable results. The CDVA improved from 0.69 ± 0.29 logarithm of the minimum angle of resolution (logMAR) at baseline to 0.35 ± 0.21 logMAR at 24 months postoperatively ( p = 0.16). Conclusion Pulsed light epithelium-off accelerated CXL using 30 mW/cm 2 for 8 min (7.2 J/cm 2 ) appears to be an effective treatment modality halting progression of keratoconus even after two years.
Source: International Ophthalmology
Institution: Goethe University Frankfurt
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
OpenAlex ID: W4409503201