Work

Genomic and clinical‑pathological features of mucinous cystadenocarcinoma of the breast with HER2 amplification: A case report

Year: 2025

Type: article

Abstract: Mucinous cystadenocarcinoma (MCA) of the breast is a rare, invasive carcinoma that resembles pancreatobiliary or ovarian MCA in terms of histological appearance. Most cases of MCA of the breast are negative for the estrogen receptor, progesterone receptor and ERBB2 (HER2). To the best of our knowledge, only five reports of HER2-positive MCA cases have been reported in the English language, and no reports focusing on the molecular characteristics of HER2-positive MCAs have been published. In the present study, a rare case of a 64-year-old woman with HER2-positive MCA who underwent long-term follow-up without recurrence or distant metastasis is reported. In addition, a detailed analysis of the genomic characteristics of the tumor is provided.

Source: Oncology Letters

DOI: 10.3892/ol.2025.15050

Authors: Liling Liu, Mingxian Li, Xinmin Qiu, Xirun Zheng, Guangjuan Zheng, Haifeng Yang

Institutions: Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine

Language: English

Topic: Breast Lesions and Carcinomas

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409508008

FWCI:

Cites: 22

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Related to: 10