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Dual‐Integrin‐Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy (Small 15/2025)

Year: 2025

Type: article

Abstract: Peptide Nanoarchitectonics A rationally designed self-assembling peptide, featuring dual integrin-binding motifs for α5β1 and αvβ3, forms nanoparticles capable of encapsulating rhein. The resulted peptide-rhein nanoarchitectonics exhibit improved hepatic delivery and enhanced antifibrotic therapeutic effects based on the combination of multiple targets and therapeutic modules, demonstrating a promising strategy for hepatic fibrosis therapy. More in article number 2409038, Yan Huang, Xuehai Yan, Qianli Zou, and co-workers.

Source: Small

DOI: 10.1002/smll.202570115

Authors: Bowen Li, Jianwei Bao, Yan Huang, Jikang Liu, Xuehai Yan, Qianli Zou

Institutions: Anhui Medical University, Chinese Academy of Sciences, Institute of Process Engineering

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4409509235

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