Work

Synthesis, characterization and biological activity of methotrexate-derived salts in lung cancer cells

Year: 2025

Type: article

Abstract: = 1.71 ± 0.23) in A549. These three MTX salts also demonstrated intrinsic apoptosis, avoiding necrosis and the formation of reactive oxygen species.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00960f

Authors: Dário Silva, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes, Luis C. Branco

Institutions: LAQV Requimte, Unidade em Ciências Biomoleculares Aplicadas, Laboratório de Análises LAQV-REQUIMTE, Universidade Nova de Lisboa

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Universidade Nova de Lisboa, Applied Molecular Biosciences Unit, Rede de Química e Tecnologia, Laboratório Associado para a Química Verde, Fundação para a Ciência e a Tecnologia

Awards: G1348429418, G3697640993, Unidade de Ciências Biomoleculares Aplicadas, G3993711494, G5610034052, G6606351954, G6776991649, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Instituto para a Saúde e a Bioeconomia, G716833851, Novel Ionic Pharmaceutical systems as targeted therapy drugs for lung cancer, G949874453

OpenAlex ID: W4409510333

FWCI: 0.289

Cites: 31

Cited by: 1

Related to: 10