Fatal Acute Intestinal Obstruction with Hemophagocytic Lymphohistiocytosis and Multiple Organ Failure in Adult-Onset Still’s Disease: A Rare Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by unpredictable multi-organ involvement. Although gastrointestinal complications are uncommon in AOSD, they can be life-threatening and present significant diagnostic and management challenges. Case Summary: We report the case of a 68-year-old man with AOSD who developed acute intestinal obstruction, a rare and critical complication. Imaging revealed significant colonic wall thickening, with a maximum thickness of 2.6 cm on contrast-enhanced computed tomography. The clinical status of the patient deteriorated, further complicated by the onset of hemophagocytic lymphohistiocytosis (HLH) and multi-organ failure, including acute renal dysfunction. Despite receiving intensive care and aggressive treatment, including supportive measures and immunosuppressive therapy, the patient succumbed to his illness. Conclusion: This case underscores the importance of recognizing rare gastrointestinal and systemic complications in patients with AOSD. Early identification and prompt multidisciplinary management of conditions such as HLH and acute intestinal obstruction are essential for improving outcomes in such critical scenarios. Keywords: acute intestinal obstruction, acute intestinal pseudo-obstruction, adult-onset Still’s disease, autoimmune disease, colonic, critical care, hemophagocytic lymphohistiocytosis, macrophage activation syndrome, multiple organ failure, multidisciplinary team (MDT)
Source: Journal of Inflammation Research
DOI: 10.2147/jir.s509898
Authors: Kun Li, Xuejia Pan, Hongyu Guo, Saiping Jiang, Xueling Fang
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,836
OpenAlex ID: W4409510631