Work

Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00524

Authors: Yihui Song, Xiangli Ren, Xinyu Yang, Jinbo Xiong, Wenwen Wang, Kai Tang, Bin Yu

Institutions: Fujian Medical University, Zhengzhou University

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Natural Science Foundation of Henan Province, Fujian Medical University, Key Scientific Research Project of Colleges and Universities in Henan Province, Chunhui Project Foundation of the Education Department of China

Awards: G1146979870, G2847904908, G353329675, G3596928240, G4416888503, G5178398261, G669073332, G6719731785

OpenAlex ID: W4409511514

FWCI: 0.522

Cites: 48

Cited by: 2

Related to: 10