Year: 2025
Type: article
Abstract: Background: Although the efficacy of triple therapy in treating chronic obstructive pulmonary disease (COPD) patients with a history of exacerbation is well established in groups with frequent exacerbations, less research has been conducted on its use in group B. Here, we investigated the effects of triple therapy on COPD patients with low eosinophil counts in the context of the current management of group B. Methods: Using data from the Korean COPD Subtype Study (KOCOSS), we selected patients with blood eosinophil count (BEC) less than 300 cells/μL as non-eosinophilic COPD groups.The study evaluated the effect of a triple therapy group (combination of inhaled corticosteroid, a long-acting β2-agonist [LABA] and a long-acting muscarinic antagonist [LAMA]) and a dual therapy group (LABA/LAMA) on moderate-to-severe exacerbations, as well as longitudinal changes in lung function over 3 years in patients categorized as Global Initiative for Chronic Obstructive Lung Disease (GOLD) B. Results: Of the 328 non-eosinophilic COPD group B, 145 (44.2%) patients were in triple therapy and 183 (55.8%) patients were in dual therapy.Triple therapy group showed an increased risk of moderate-to-severe exacerbation in multivariate adjusted model (adjusted incidence rate ratio of annual rate, 2.04; 95% confidence interval, 1.45 to 2.84; P < 0.001).Similarly, restricted cubic spline regression analysis of annual rates of moderate-to-severe exacerbations suggested an increased risk associated with the triple therapy over dual therapy in BEC lower than 300 cells/μL.There was no significant difference in the adjusted rate of forced
Institutions: Veterans Health Service Medical Center, Soonchunhyang University Hospital Bucheon, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Konkuk University, Konkuk University Medical Center, University of Ulsan, Ulsan University Hospital, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, Hallym University Chuncheon Sacred Heart Hospital, Seoul National University, Seoul Metropolitan Government, SNUH SMG-SNU Boramae Medical Center, The Catholic University of Korea Yeouido St. Mary's Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $690
OpenAlex ID: W4409515246