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Proliferative glomerulonephritis with monoclonal immunoglobulin deposition coexisting with ANCA-associated glomerulonephritis: a case report

Year: 2025

Type: article

Abstract: Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID) is a rare variant of monoclonal gammopathy of renal significance (MGRS). Although the pathogenesis of PGNMID is not yet fully understood, it is currently hypothesized to originate from the intraglomerular deposition of pathogenic monoclonal immunoglobulins secreted by B cells or plasma cells. Typically, these deposits exhibit light chain restriction, with κ light chains being the most prevalent. Therapeutic strategies for PGNMID are based on targeting the abnormal or potential clone. However, the combination of corticosteroids and cyclophosphamide has also been reported. In this report, we describe an extremely rare clinical case of λ light chain type PGNMID occurring simultaneously with ANCA-associated glomerulonephritis. After treatment with the combination of corticosteroids and cyclophosphamide, the patient demonstrated reduced proteinuria and stable renal function.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2025.1567277

Authors: Yaqian Cheng, Yifan Zhang, Hui Chen, Yiyi Zheng, Zemin Wang

Institution: Wenzhou Central Hospital

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801