Work

Proteogenomic Analysis of Healthy and Cancerous Prostate Tissues Using SILAC and Mutation Databases

Year: 2025

Type: article

Abstract: Prostate cancer is the second most diagnosed cancer in men worldwide and a significant cause of cancer-related death. Proteogenomic analysis offers insights into how genomic mutations influence protein expression and can identify novel biomarkers. This study aimed to investigate the impact of missense mutations on protein abundance in prostate cancer versus healthy tissues using SILAC-based quantitative proteomics.

Source: Oncology Advances

DOI: 10.14218/ona.2024.00032

Authors: Giullia de Souza Santos, Rafaela Marie Melo da Cunha, Ricardo Alves da Silva, Thauan Costa da Silva, Thiago Antonio Costa do Nascimento, Lucas Marques da Cunha

Institution: Universidade Federal de Rondônia

Language: English

Topic: Advanced Proteomics Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Universidad Internacional de La Rioja, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul