Work

Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells

Year: 2025

Type: article

Abstract: Here, we demonstrate a novel interplay between cell-cell and cell-matrix adhesions, showing that fibronectin-dependent integrin signaling promotes NF-κB activation and interaction with the EphA2 promoter to drive smooth muscle EphA2 expression, whereas integrin inhibition attenuates EphA2 expression in atherosclerotic plaques in vivo. Although this relationship has clear implications on smooth muscle fibroproliferative remodeling in atherosclerosis, the matrix-specific regulation of EphA2 expression may impact a variety of pathological conditions.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.01021.2024

Authors: Brenna Pearson-Gallion, Alexandra C. Finney, Matthew L. Scott, Zachary Connelly, Shafiul Alam, Jonette M. Peretik, Cyrine Ben Dhaou, Md. Shenuarin Bhuiyan, James G. Traylor, William F. DeGrado, Hyunil Jo, Xiuping Yu, Oren Rom, Christopher B. Pattillo, Nirav Dhanesha, Arif Yurdagul, A. Wayne Orr

Institutions: Louisiana State University, Louisiana State University Health Sciences Center Shreveport, University of South Florida, University of California, San Francisco

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, Louisiana State University Shreveport, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, LSU Health Shreveport

Awards: G1057096545, G1277892170, G1361688239, Sigmar1 autophagic function in protecting cardiac proteotoxicity, G1422481426, G1939050324, G2126352504, G2346181502, Mechanisms of glycine-based therapy for atherosclerosis, G2821732114, G2834765407, G2982302453, G3007980176, G3177103379, G3689269546, G3819032134, Nck adaptor proteins in atherogenic endothelial activation, G4246919793, Androgen Deprivation Activates Wnt/Beta-Catenin Signaling in Prostate Cancer, EphA2 signaling mechanisms in smooth muscle proliferation and migration in atherosclerosis, G5203222050, G5237076519, G596644751, EphA2 in Non-Alcoholic Fatty Liver Disease, G6332918016, G6747443208, Mechanisms of glycine-based therapy for atherosclerosis, EphA2 Mediates Vascular Smooth Muscle Fibroproliferative Response in Vascular Remodeling, G7234455988, Processing of Apoptotic Cell-Derived Cargo by Macrophages Continues Efferocytosis and Drives Atherosclerosis Regression, G75335528, G7686625447, G7897112823, G8530776518, Center for Redox Biology and Cardiovascular Disease, Novel mitophagy regulatory mechanism in heart failure

OpenAlex ID: W4409520047

FWCI: 2.543

Cites: 75

Cited by: 4

Related to: 10