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Integrating Lifestyle Modifications and Advanced Sperm Separation Technology: A Case Study on Overcoming Male Infertility Using the LensHooke CA0 Device

Year: 2025

Type: article

Abstract: This study describes the disadvantages of the centrifugation method along with the utilization of high-technology sperm separation to overcome infertility. A 31-year-old female and a 36-year-old male were presented with primary infertility in Maharashtra. The female had normal hormonal profiles; however, the male had a sperm deoxyribonucleic acid (DNA) fragmentation (SDF) index of 46%, which may be due to lifestyle factors such as occupational exposure to chemicals and alcohol use. The contribution to the rise in the SDF was previously due to conventional density gradient centrifugation. To reduce the SDF, the male was put on two months of treatment including lifestyle modification (stress reduction, diet improvement, exercise, etc.) along with the antioxidants. Following this, the sperm was separated through the LensHooke CA0 device that avoids centrifugation. This reduces oxidative stress and DNA damage using a natural motility-based sorting mechanism. Post-treatment, the SDF decreased dramatically to 17%. The couple became pregnant with IUI. This case shows that the LensHooke CA0 device effectively lowers SDF, while ART outcomes improve. These results highlight that lifestyle modification should be implemented along with modern, minimally invasive sperm separation procedures for male infertility treatment.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_172_25

Authors: Juhi Barai, Akash More, Namrata Choudhary, Aru Chaudhary, Puja Dhamija, Ganesh Laxman Kalaskar

Institution: Datta Meghe Institute of Higher Education and Research

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250