Work

Coexistence of BCR–ABL1 reassortment and JAK2 V617F mutation in chronic myeloid leukaemia

Year: 2025

Type: article

Abstract: Myeloproliferative neoplasms (MPNs) can be classified into two major categories, namely chronic myeloid leukaemia (CML) and Philadelphia-negative MPNs (PN-MPNs). BCR- ABL1 reassortment is an irreplaceable indicator for the diagnosis of typical CML, while the V617F mutation on the Janus kinase 2 (JAK2) gene is common in PN-MPNs patients. Generally, these two genetic abnormalities are considered unable to coexist. We report a patient with CML who had both genetic changes, suggesting that when tyrosine kinase inhibitors (TKIs) monotherapy cannot obtain satisfactory treatment outcomes in CML patients, another possibility besides disease progression is a mutation on the JAK2 V617F gene.

Source: The National Medical Journal of India

DOI: 10.25259/nmji_61_2022

Authors: JIANJUN YANG CHEELOO, KEHONG BI, ZHAOGUANG ZHANG

Institutions: Shandong University, Shandong First Medical University

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409524267

FWCI:

Cites: 7

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Related to: 10