Effects of Ovarian Cancer Cell-Derived Extracellular Vesicles on The Proliferation and Expression Levels of Gdf-9, Amh, Igf1r and Foxl2 in Mouse Granulosa Cells.
Year: 2025
Type: article
Abstract: OBJECTIVE: Granulosa cell tumor (GCT) is a sex cord-stromal rare malignancy; and is associated with infertility. Extracellular vesicles (EVs) are small secreted vesicles containing proteins, mRNA, and miRNA, therefore modulating signaling pathways potentially in recipient cells and in this way, they can help cancer spread through intercellular communication. In this research, the capability of ovarian cancer-derived EVs for inducing proliferation and metastasis in GCs is investigated. MATERIALS AND METHODS: were determined using real-time polymerase chain reaction (PCR). RESULTS: gene was decreased in comparison with the control. CONCLUSION: To sum up, the research here provides a novel insight into the role of ovarian cancer EVs in proliferation and metastasis in GCs and prevention of infertility caused by granulosa cancer.
Source: PubMed
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4409525653