Meta-analysis of animal experiments on osteogenic effects of trace element doped calcium phosphate ceramic/PLGA composites
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objectives Investigate the impact of the components in element-doped calcium phosphate ceramic/PLGA composites on bone repair outcomes in animal experiments. Methods Computer search of CNKI, Wanfang, Pub Med, Web of science, and EMbase databases to collect related randomized controlled animal experimental studies. Using the SYRCLE Animal Experimental Bias Risk Assessment form to evaluate research quality. The outcome measures were statistically analyzed using the Rev Man 5.4 software. Results Included 11 randomized controlled animal studies. Meta-analysis showed that: (1) Element doping can promote the proliferation of osteoblasts in vitro. (2) Element doping can increase the activity of ALP in cells. (3) Element doping can increase bone volume fraction. (4) Element doping can increase trabecular number. Conclusions Trace element doping has been found to enhance the osteogenic effect of the composite material. The type of calcium phosphate ceramics may be a significant source of heterogeneity that influences the effectiveness of bone repair in vivo.
Authors: Hongwei He, Meng Zhong, Panxianzhi Ni, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
Institution: Sichuan University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid:
Award: G6237835754
OpenAlex ID: W4409526309