Work

Beyond the ends: potential implications of telomeric repeat-containing RNA (TERRA) for CNS diseases

Year: 2025

Type: article

Abstract: Telomeric repeat-containing RNA (TERRA) is a class of non-coding RNAs emanating from telomeres and controlling telomere dynamics. Recent studies showed that TERRAs influence chromatin structure and gene expression. TERRAs can also play a crucial role in controlling inflammation, oxidative stress, DNA damage, and cellular senescence. This review discusses the significance of TERRAs in modulating these processes, particularly in the central nervous system (CNS). While our understanding of TERRAs largely stems from cancer research, their involvement in these physiologic and pathologic pathways highlights their potential as therapeutic targets for CNS disorders as well.

Source: Journal of Molecular Cell Biology

DOI: 10.1093/jmcb/mjaf013

Authors: Hadjer Namous, Raghu Vemuganti

Institutions: University of Wisconsin–Madison, William S. Middleton Memorial Veterans Hospital

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900