Work

Effects of reducing sedentary behavior on liver insulin sensitivity, liver fat content, and liver enzyme levels: a six-month randomized controlled trial

Year: 2025

Type: article

Study design: Clinical Trial

Abstract: Aiming to reduce sedentary behavior (SB) by 1 h/day did not significantly influence liver health markers, suggesting that more substantial reductions or a different approach might be necessary to see improvements. However, achieving the desired behavioral change could lead to improvements in ALT levels. This study is the first to analyze how reducing SB and replacing it with nonguided physical activity impacts liver health in adults with metabolic syndrome, offering insights for future intervention strategies.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00446.2024

Authors: Saara Laine, Tanja Sjöros, Taru Garthwaite, Miikka-Juhani Honka, Eliisa Löyttyniemi, Jooa Norha, Olli Eskola, Mikko Koivumäki, Henri Vähä-Ypyä, Harri Sievänen, Tommi Vasankari, Jussi Hirvonen, Kirsi Laitinen, Noora Houttu, Kari K. Kalliokoski, Virva Saunavaara, Juhani Knuuti, Ilkka H. A. Heinonen

Institutions: Åbo Akademi University, University of Turku, Turku University Hospital, Turku PET Centre, Urho Kaleva Kekkonen Institute, Tampere University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Yrjö Jahnssonin Säätiö, Wellcome Trust, Academy of Finland, Juho Vainion Säätiö, Turun Yliopisto, Åbo Akademi, Instrumentariumin Tiedesäätiö, Varsinais-Suomen Sairaanhoitopiiri, Turun Yliopistollinen Keskussairaala, Turun Yliopistosäätiö

Awards: G4001648815, G5932381397, G6518863367, Talking Mental Health (working title), G6804816222, G7290657319, G8099111449, Exercise and tumor blood flow, hypoxia and metabolism

OpenAlex ID: W4409528610

FWCI: 4.984

Cites: 72

Cited by: 8

Related to: 10