Year: 2025
Type: article
Abstract: REVIEW HFpEF as an interdisciplinary problem 1 filling pressures and clinical symptoms such as dyspnea, fatigue, and exercise intolerance.2 HFpEF is closely linked to several metabolic and cardiovascular disorders, including type 2 diabetes mellitus (T2DM), hypertension, obesity, and atrial fibrillation (AF).T2DM promotes myocardial fibrosis, endothelial dysfunction, and systemic inflammation, all of which contribute to the pathogenesis of HFpEF. 3 Hypertension is a major driver of LVH and arterial stiffness, exacerbating diastolic dysfunction and increasing the likelihood of HFpEF development.4 Obesity, particularly central adiposity, is associated with increased myocardial workload, inflammation, and altered cardiac metabolism, further predisposing individuals to HF-pEF. 5 AF, frequently observed in patients with HFpEF, worsens diastolic dysfunction by causing tachycardia -induced cardiomyopathy and a
Source: Przegląd Lekarski
Authors: Patrycja Mołek‑Dziadosz, Jadwiga Nessler
Institution: Jagiellonian University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409528978