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LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease (Adv. Sci. 15/2025)

Year: 2025

Type: article

Abstract: Dysfunction-Associated Steatotic Liver Disease High-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis. LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH. More details can be found in article number 2415941 by Yongmin Yan and co-workers.

Source: Advanced Science

DOI: 10.1002/advs.202570110

Authors: Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

OpenAlex ID: W4409533525

FWCI:

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