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The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ (Adv. Sci. 15/2025)

Year: 2025

Type: article

Abstract: Fetal Growth Restriction Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus participate in the transcriptional regulation of downstream genes, which is not identical to that of endogenous PPARγ in preadipocytes. Compromised PPARγ in the placenta causes deficient adipogenesis in the fetus and intruterine growth restriction but can be rescued by placenta-targeted activation of PPARγ. More details can be found in article number 2404983 by Hongbo Qi, Chao Tong, and co-workers.

Source: Advanced Science

DOI: 10.1002/advs.202570108

Authors: Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

OpenAlex ID: W4409533533

FWCI: 1.037

Cites:

Cited by: 1

Related to: 10