Year: 2025
Type: article
Study design: Observational Study
Abstract: B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn's disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients.
Source: Nature Communications
Authors: Prasanti Kotagiri, William M. Rae, Laura Bergamaschi, Diana Pombal, Ji-Yeun Lee, Nurulamin M. Noor, Raoul S. Sojwal, Samuel J. S. Rubin, Lukas W. Unger, Sofie H. Tolmeijer, Giulia Manferrari, Rachael J. M. Bashford-Rogers, David B. Bingham, Anton Stift, Stephan Rogalla, John Gubatan, James C. Lee, Kenneth G. C. Smith, Eoin F. McKinney, Scott D. Boyd, Paul A. Lyons
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: Yale University, Wellcome Trust, Francis Crick Institute, Cancer Research UK, National Institute for Health and Care Research, Research Councils UK, Austrian Science Fund, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute of Diabetes and Digestive and Kidney Diseases, Medical Research Foundation
Awards: G1233564986, G2573804016, G2616594142, A new biology of clinical outcome in immune-mediated disease, Improving long term outcomes post kidney transplant through study of the immune receptor repertoire, G4491951056, A BIOMARKER AND PATHWAY DISCOVERY PROGRAMME IN INFLAMMATORY DISEASE, G5497690081, G5580698412, G5864510356, G6564290625, InSIGHT: Integrating Statistical methods, Immunology and Genomics for Healthcare Translation, The role of FAMIN in cancer development, G7211818217, G8216345017
OpenAlex ID: W4409533621