Work

Family history of diabetes mellitus and risk of colorectal cancer: A nationwide cohort study

Year: 2025

Type: article

Abstract: AIMS: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. METHODS: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964-2018) to compare the risk using standardized incidence ratio (SIR). RESULTS: 11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39-1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset CRC. CONCLUSION: Leveraging one of the world's largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.

Source: Diabetes Research and Clinical Practice

DOI: 10.1016/j.diabres.2025.112187

Authors: Zehui Chen, Elham Kharazmi, Qunfeng Liang, Kristina Sundquist, Jan Sundquist, Mahdi Fallah

Institutions: German Cancer Research Center, Lund University, Region Skåne, University of Bern

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,410