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Longitudinal MRI Assessment of Brain Changes in Parkinson’s Disease

Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Parkinson's disease (PD) is clinically heterogeneous, with REM sleep behavior disorder (RBD) playing a key role in subtyping forms of the disease. Proposed models of progression do not take all variations into account. We investigated the spatiotemporal brain changes in regions of interest (ROIs) associated with Braak stages of PD including brainstem, basal ganglia, thalamus and medial temporal lobe regions using MRI biomarkers and multivariate modelling to classify different disease trajectories
DOI: 10.1016/j.parkreldis.2025.107425
Authors: E. Kozlowski, R. Valabregue, S. Ouarab, M. Didier, R. Gaurav, J.B. Pérot, F.X. Lejeune, G. Jimenez, S. Ruyter, N. Pyatigorskaya, I. Arnulf, J.C. Corvol, M. Vidailhet, S. Lehéricy, D. Racoceanu
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,460
OpenAlex ID: W4409534400
FWCI:
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