A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation
Year: 2025
Type: article
Study design: Observational Study
Abstract: monocytes. We found that the antigen processing-related pathway is dysregulated in immune cells of patients with WD. Our study revealed that abnormal copper concentration influences the expression of HLA-I and HLA-II molecules. It is noteworthy that a high concentration of intracellular copper differs significantly from the high concentration of extracellular copper. We have also identified a gene set of neurologic abnormalities, which were dysregulated in PBMCs of patients with WD. We also observed abnormal expression of cuproptosis-associated genes in proliferating or malignant cells, providing new insights into the application of cuproptosis in cancer treatment.
Source: iScience
Authors: Shuya Wang, Xianlei Sun, Qingxuan Xin, Jianxiang Shi, Jin Li, Huilin Zhang, Mengjiao Xue, Fanxiang Yin, Zan Qiu, Xiaoqian Wang, Nannan Sun, Yingmei Li, Yaoyao Chen, Liyan Fu, Chaoqi Li, Shaohua Yan, Xian Zhao, Bolin Jue, Yanxia Gao, Baohong Yue, Bo Qin, Yong Jiang, Rongqun Guo
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: National Natural Science Foundation of China, Natural Science Foundation of Henan Province, Natural Science Foundation for Distinguished Young Scholars of Hunan Province, National Key Research and Development Program of China, Key Scientific Research Project of Colleges and Universities in Henan Province
OpenAlex ID: W4409534694