Structural knee MRI findings are already frequent in a general population-based birth cohort at 33 years of age
Year: 2025
Type: article
Abstract: OBJECTIVE: To evaluate the incidence and severity of knee magnetic resonance imaging (MRI) findings and their associated lifestyle and health factors in a relatively healthy subset of a general population-based birth cohort. DESIGN: The study population (n = 288, 61.1% females, mean age 33.7 years) is a subpopulation of the Northern Finland Birth Cohort 1986 on whom a thorough clinical evaluation, laboratory analyses and knee MRI were conducted at 33 years of age. Knee MRI data was graded using the MRI Osteoarthritis Knee Score system. Descriptive statistics and multivariable regression models were used for data analysis. RESULTS: Subjects were mostly asymptomatic. Detected articular cartilage lesions were mostly small and identified in 56.2% (n = 162) of patellofemoral and 25.3% (n = 63) of tibiofemoral joints. Full-thickness cartilage lesions and bone marrow lesions were mostly located in the patellofemoral joint. Osteophytes, mostly small or doubtful, were detected in 51.7% (n = 146) of patellofemoral and 17.4% (n = 41) of tibiofemoral joints. In finding-specific regression analyses, higher body mass index (BMI) was most frequently associated with knee MRI findings. CONCLUSIONS: In this relatively young and asymptomatic population, subtle knee MRI findings were already frequent, especially in the patellofemoral joint. Of analyzed background and clinical parameters, higher BMI was most frequently associated with MRI findings. Based on these results, longitudinal studies are warranted to further identify risk factors and proportions of progressing MRI findings.
Source: Osteoarthritis and Cartilage
Institutions: Oulu University Hospital, University of Oulu
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,700
OpenAlex ID: W4409535182