Work

Highly Efficient and Sustainable HT@NC/Pd Catalysts for Suzuki Coupling and Their Application in Elacestrant Synthesis

Year: 2025

Type: article

Abstract: Mg-Al hydrotalcite (HT), comprising Mg2+ and Al3+ as layered hydroxide cations, was synthesized via a hydrothermal process at 200 °C. The HT was evaluated as a carrier, and subsequently, palladium was immobilized on the surface of the hydrotalcite (HT/NC), resulting in the development of an innovative biomass-based palladium catalyst. The catalyst underwent analysis by X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). It exhibited remarkable catalytic efficiency and superior activity as a catalyst in the Suzuki–Miyaura coupling reaction in water. The catalyst was recyclable without a decline in activity and could be utilized more than 10 times, with exceptional yield. Furthermore, the commercially accessible anticancer drug Elacestrant can be readily produced using this protocol.

Source: Catalysts

DOI: 10.3390/catal15040389

Authors: Jiajun He, Muwei Liu, Chao Chen, Guozhang Li, Kai Zheng, Chao Shen

Institutions: Changzhou University, Zhejiang Shuren University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $2,654