Novel_circ_0004013 targeting miR-29a-3p affects age-related hearing loss in miR-29a mouse model by RNA-seq analysis
Year: 2025
Type: article
Abstract: mice. Furthermore, Western blot assays revealed that levels of oxidative stress and apoptosis were significantly decreased in HEI-OC1 cells following the knockdown of novel_circ_0004013, whereas these levels were significantly increased in HEI-OC1 cells after the knockdown of miR-29a-3p. It was indicated in rescue assays that novel_circ_0004013 expedited oxidative stress and apoptosis of HEI-OC1 cells via modulation on miR-29a-3p. These findings may reveal the important role of novel_circ_0004013 in hearing loss and provide a new perspective and theoretical basis for the molecular mechanism of ARHL.
Source: Experimental Gerontology
Authors: Mulan Li, Bingqian Li, Shuli Wang, Pengcheng Liu, Zhen Liu, Tihua Zheng, Ruishuang Geng, Bo Li, Qingyin Zheng, Peng Ma
Institution: Binzhou Medical University
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,400
Awards: G3937249057, G7233790827, G7349606739
OpenAlex ID: W4409537978