Work

Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients

Year: 2025

Type: article

Abstract: BACKGROUND: This study aimed to explore the relationship between self-reported sleep disturbances (e.g., insomnia, REM sleep behavior disorder [RBD]) and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease (PD) patients. METHODS: We conducted a cross-sectional study comparing 100 PD patients (observation group) with 100 age-matched controls. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and serum levels of amyloid-beta (Aβ1-42), α-synuclein, and inflammatory markers (CRP, TNF-α, IL-1β) were quantified. RESULTS: , P = 0.007) compared to controls. Biomarker profiling revealed elevated amyloid pathology in PD, with higher serum Aβ1-42 (median [IQR]: 1.98 [1.75-2.22] vs. 1.14 [1.10-1.19], P < 0.001) and α-synuclein (2.03 [1.85-2.22] vs. 1.06 [1.03-1.10], P < 0.001). Proinflammatory markers were markedly increased in PD, including CRP (9.30 [7.85-10.75] vs. 6.30 [5.60-7.10], P = 0.01), TNF-α (372.20 [329.85-414.55] vs. 184.50 [165.20-203.80], P < 0.001), and IL-1β (573.50 [497.15-649.85] vs. 115.40 [101.05-129.75], P < 0.001). Multivariate analysis identified cortical thinning, brainstem atrophy, and IL-1β elevation as independent predictors of sleep disturbances (P < 0.05). CONCLUSION: These findings highlight the interplay between neuroanatomical changes, amyloid pathology, and systemic inflammation in PD-related sleep dysfunction, suggesting potential therapeutic targets.

Source: Experimental Gerontology

DOI: 10.1016/j.exger.2025.112762