Work

Development of Hydrofluoroolefin (HFO)‐Based Direct O ‐Fluoroalkenylation of Phenols Targeting Tyrosine Conjugation

Year: 2025

Type: article

Abstract: Methodology for direct fluoroalkenylation of phenolic OH function was developed using a fluorinated electrophilic reagent derived from HFO1234ze gas. Besides various functionalized phenols, tyrosine and tyrosine‐based peptides were successfully conjugated under the optimized reaction conditions. Furthermore, the transformability of the fluoroalkenyl bromide motif was demonstrated to expand the space of bioconjugation via palladium catalyzed cross‐coupling reactions.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202500282

Authors: Rihárd Sisa, Ferenc Béke, Zoltán Novák

Institution: Eötvös Loránd University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Magyar Tudományos Akadémia, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, Servier, National Research, Development and Innovation Office