Year: 2025
Type: article
Abstract: Transition metal‐catalyzed cascade cyclization of allenynes is regarded as an efficient approach for the synthesis of versatile cyclic frameworks. However, catalytic asymmetric cascade cyclizations of allenynes are still uncommon. Herein, we present the first cobalt‐catalyzed enantioselective alkenylative cyclization of 1,6‐allenynes with readily available alkenylboronic acids, providing five‐membered carbo‐ and heterocycles with high efficiency (up to 97% yield), broad substrate scope, and moderate to good enantioselectivities (up to 95:5 er).
Source: Advanced Synthesis & Catalysis
Authors: Tao Wang, Ji‐Xun Guan, Yun‐Xuan Tan, Ping Tian
Institution: Shanghai University of Traditional Chinese Medicine
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G6616854509, G8395093772
OpenAlex ID: W4409543687