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Innovative dual-pump regulation in veno-arteriovenous extracorporeal membrane oxygenation: A Single‐center experience

Year: 2025
Type: article
Study design: Case Report
Abstract: PURPOSE: To evaluate the safety and efficacy of veno-arteriovenous extracorporeal membrane oxygenation (V-AV ECMO) with a secondary centrifugal pump to control blood flow in return pathways as an alternative to the conventional Hoffman clamp. MATERIALS AND METHODS: We conducted a retrospective review of all adult patients who underwent V-AV ECMO in our hospital from January 1, 2022, to December 31, 2023. Data, including demographic characteristics, comorbidities, and ECMO-specific information, were systematically extracted from electronic medical records. RESULTS: Five patients, three (60 %) of whom were male, underwent V-AV ECMO. Four patients were initially placed on veno-venous extracorporeal membrane oxygenation (V-V ECMO), and one was placed on veno-arterial extracorporeal membrane oxygenation (V-A ECMO). The mean duration of V-AV ECMO support was 14.4 ± 11.4 days. Ventilator support was reduced, and fewer vasoactive drugs were administrated. Hemoglobin and platelets tended to decrease in all five patients, but D-dimer did not increase. No patients experienced active bleeding, and one patient developed oxygenator thrombosis. Two patients survived to discharge. CONCLUSION: V-AV ECMO using a secondary centrifugal pump is feasible and likely safe without increasing the risk of ECMO-related complications such as hemolysis, thrombocytopenia, blood clot formation, or clotting factor consumption. Future prospective studies are warranted to validate these findings and optimize ECMO management protocols.
DOI: 10.1016/j.rmed.2025.108108
Authors: Guangyun Huang, Ying Liu, Zhiyong Yuan, Huimin Ge, Fuhua Wang, Jinyan Xing
Language: English
Open Access status: hybrid
Estimated APC paid: $3,630
OpenAlex ID: W4409545072
FWCI:
Cites: 20
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Related to: 10