Work

Photoinduced enantioselective transformations via o-quinodimethane intermediates

Year: 2025

Type: article

Abstract: The effective stereoselective control of transient intermediates remains a formidable challenge in synthetic chemistry. o -Quinodimethane generated by photo-irradation has been extensively investigated and widely utilized as a nucleophilic surrogate. Nevertheless, enantioselective transformations involving o -quinodimethane are still underdeveloped, due to the persistent challenges in intercepting these intermediates and achieving effective stereoselective control with chiral catalysts. In this review, we summarize recent advances in photoinduced enantioselective reactions of o -quinodimethane, highlighting catalytic strategies, mechanistic insights, and current limitations in the field.

Source: Tetrahedron Chem

DOI: 10.1016/j.tchem.2025.100131

Authors: Liwen Xia, Qingqin Huang, Zhao-Fei Zhang, Lei Dai

Institutions: National University of Singapore, Chongqing University, Purdue University West Lafayette

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,660

Funders: National Natural Science Foundation of China, Chongqing University, Centre Scientifique et Technique du Bâtiment, Fundamental Research Funds for the Central Universities