Graphene Derivatives as Efficient Transducing Materials for Covalent Immobilization of Biocomponents in Electrochemical Biosensors
Year: 2025
Type: article
Abstract: This review highlights the role of graphene derivatives in advancing electrochemical biosensors for applications in diagnostics, environmental monitoring, and industrial sensing. Graphene derivatives, including graphene oxide (GO), reduced GO, and wide range of graphenes prepared via fluorographene chemistry, represent a prominent class of transducing materials in electrochemical biosensor development. Their ability to support covalent immobilization of biocomponents ensures stability, specificity, and long‐term performance, addressing limitations of noncovalent methods. Advances in fabrication, such as laser‐assisted reduction, enable scalable and cost‐effective production of conductive graphene‐based electrodes. Covalent functionalization techniques, like carbodiimide coupling and click chemistry, facilitate integration with bioreceptors, leading to highly selective biosensors. Emerging approaches, including inkjet printing of graphene‐based inks onto eco‐friendly substrates, promise sustainable and portable diagnostic devices. These advances support biosensors aligned with modern and sustainable technologies. Future efforts must focus on scalable production, improved multiplexing, and environmental sustainability to fully harness the potential of graphene derivatives in electrochemical biosensors.
Source: ChemElectroChem
Institutions: Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, VSB - Technical University of Ostrava, Charles University, Institut Català de Nanociència i Nanotecnologia, Barcelona Institute of Science and Technology, Institució Catalana de Recerca i Estudis Avançats, Academy of Sciences of Albania, University of Tirana
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,750
Funders: Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, Institut Català de Nanociència i Nanotecnologia, European Commission, Generalitat de Catalunya, HORIZON EUROPE Framework Programme, European Regional Development Fund, Agencia Estatal de Investigación, European Social Fund
Awards: G1105844351, G1153767801, G1417226337, G1492781007, G1983217342, G2262748287, Twinning to boost the scientific and innovation capacity of the Universiteti i Tiranes to develop sustainable nanosensors for water pollution detection, G291036901, G3005324705, G3106101616, G3346903504, G3480869486, G354764522, G3735356012, G3771185154, G4042783231, G4273056302, G4472258033, G5080475149, G535059049, G5602316953, G5706383408, G5967599077, G6033112984, G6218905885, G6253592498, G6532547617, G6605876378, G6656126374, G675437911, G6762955466, G7058863520, G7084143925, G7626803220, G7799207878, G7805626310, Supple Graphene Bio-Platform for point-of-care early detection and monitoring of Alzheimer’s Disease, G8497050386
OpenAlex ID: W4409547854