Work

Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease

Year: 2025

Type: article

Abstract: T cells in some participants in the highest dose IM and IV cohorts. Anti-drug antibodies decreased exposure of SBT115301 in some participants without affecting the pharmacodynamics. These data support further study of SBT115301 as a monotherapy or in combination with other drugs in autoimmune indications.

Source: iScience

DOI: 10.1016/j.isci.2025.112447

Authors: Herve Lebrec, John Bui, Jonathan M. Clingan, Jason Do, Jason Dubovsky, Leonard Dragone, Ekaterina Gibiansky, Wing Yu Lam, Katherine Matsuda, Lauren Mihalcik, Frederick Ramsdell, Anne-Renee van der Vuurst de Vries, Yuanyuan Xiao, Jeffrey A. Bluestone

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

OpenAlex ID: W4409548306

FWCI: 0.886

Cites: 40

Cited by: 3

Related to: 10