Work

A triosmium carbonyl cluster that inhibits α-synuclein aggregation and disassembles preformed aggregates

Year: 2025

Type: article

Abstract: (2), effectively inhibited α-synuclein aggregation, a key signature of Parkinson's disease (PD), in both wild-type and A53T-mutant α-synuclein models. Cluster 2 showed superior efficacy and a significantly better safety profile, and could also disassemble preformed aggregates.

Source: Chemical Communications

DOI: 10.1039/d5cc01141h

Authors: Xin Liang, Balasz Gulyas, Mathangi Palanivel, Weng Kee Leong

Institution: Nanyang Technological University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Ministry of Education - Singapore