Long Noncoding RNA LINC02487 in the Proliferation and Metastasis of Triple-Negative Breast Cancer Cells
Year: 2025
Type: article
Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and a leading cause of cancer-related mortality in women. The incidence of TNBC is particularly high in China, yet treatment options remain limited, with chemotherapy—often associated with severe side effects—being the primary therapeutic approach. This study investigates the role of LINC02487 in TNBC through in vitro experiments to assess its potential as a biomolecular marker for TNBC treatment. RT-qPCR analysis revealed that LINC02487 expression was significantly upregulated in TNBC. Lentiviral transfection was used to establish LINC02487 overexpression cell lines. CCK-8 assays and EdU staining demonstrated that LINC02487 overexpression promoted TNBC cell proliferation at 24, 48, and 72 hours. Conversely, knockdown of LINC02487 inhibited TNBC cell proliferation, as confirmed by experiments using LINC02487 knockdown cell lines. Furthermore, Transwell assays indicated that LINC02487 knockdown suppressed TNBC cell migration and invasion. Overall, this study confirms the high expression of LINC02487 in TNBC and demonstrates that its knockdown can inhibit cell proliferation and metastasis, thereby slowing TNBC progression. These findings suggest that LINC02487 has potential as a novel prognostic marker and therapeutic target for TNBC, offering new hope for improved patient outcomes.
Source: Theoretical and Natural Science
Author: Yuhan Guo
Institution: Renmin University of China
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4409550000