Recent Advances in Annulation Reactions of α,β‐Unsaturated Ketoximes for the Synthesis of Structurally Diversified Heterocycles
Year: 2025
Type: article
Abstract: Transition metal‐catalyzed or metal‐free‐mediated annulation of α,β‐unsaturated ketoximes with unsaturated coupling partners has emerged as a powerful protocol for the assembly of diverse functionalized heterocycles, which is attributed to the ability of the oxime functionality to serve as a directing group for C−H activation, to undergo reductive N−O bond cleavage, and be activated by Lewis acids or reduced by iodide salt. In this review, we summarize the coupling reactions of three types of α,β‐unsaturated ketoximes with various organic compounds containing unsaturated bonds such as alkenes, alkynes, carbonyls, nitriles and so on over the past decades. The reaction conditions, selected examples of the reaction scope, limitations, and reasonable mechanisms are critically described. Furthermore, the prospects for future challenges and opportunities are also explored.
Source: Advanced Synthesis & Catalysis
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: 微流场中酶-有机催化耦合制备聚己内酯共聚物及其机制研究
OpenAlex ID: W4409550220