Work

Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner

Year: 2025

Type: article

Abstract: Our study is the first in vivo experiment using polyomavirus middle T antigen-sex hormone-binding globulin (PyMT-SHBG) mouse model to assess the physiological role of SHBG in breast cancer development. We show that SHBG presence in PyMT model restrains breast cancer development and progression in sex hormone-independent manner.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00747.2024

Authors: Sang R. Lee, Na Rim Kim, Moeka Mukae, Young Suk Won, Eui-Ju Hong

Institutions: Chungnam National University, Dong-A University, Korea Research Institute of Bioscience and Biotechnology

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Research Foundation of Korea