Work

Increasing heterogeneity is associated with IL-6 expression in the lungs following mechanical ventilation

Year: 2025

Type: article

Abstract: The combination of low inspiratory and expiratory pressure promotes atelectasis but is not associated with markers of injury in the healthy lung during short-term ventilation. High inspiratory pressures promote tidal volume heterogeneity, which is correlated with the expression of genetic markers of lung injury. These data suggest that heterogeneity in tidal volume may be a key driver of biotrauma in the healthy, mechanically ventilated lung.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00271.2024

Authors: Ella Smalley, David Trevascus, Yong Song, Melissa Preissner, Peter A. Dargaville, Martin Donnelley, Kaye Morgan, Stephen Dubsky, Graeme R. Zosky

Institutions: University of Tasmania, Monash University, The University of Adelaide

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Department of Health and Aged Care, Australian Government, Department of Education and Training, Australian Research Council, National Health and Medical Research Council

Awards: Bridging the gap between global mechanics and regional imaging in the lungs, Linking structure and function: a new approach for understanding the lung, The link between regional lung stretch and distal organ injury in response to mechanical ventilation, G4326279123, G4937488870, G7059771372

OpenAlex ID: W4409559799

FWCI: 1.215

Cites: 45

Cited by: 2

Related to: 10