Work

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition–C–H Activation for the In-Flow Synthesis of N-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates

Year: 2025

Type: article

Abstract: -pyridyl-5-amino-1,2,3-triazole-4-carboxylate derivatives catalyzed by copper salts in a packed bed reactor. The synthetic approach takes first advantage of click chemistry, specifically relying on Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC), to achieve the efficient and selective assembly of a triazole ring, followed by a copper-mediated C-H activation, that substitutes an inert C-H bond with a C-N bond, providing an environmentally acceptable and cost-effective strategy for synthesizing highly functionalized organic molecules.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c00453

Authors: Emanuela Donato, Martha C. Mayorquín-Torres, Alessandra Puglisi, Maurizio Benaglia, Mauro F. A. Adamo, Christian V. Stevens

Institutions: University of Milan, Ghent University, Royal College of Surgeons in Ireland, Kelada Pharmachem (Ireland)

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: European Commission, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, NextGenerationEU