BioSpring : An elastic network framework for interactive exploration of macromolecular mechanics
Year: 2025
Type: article
Abstract: BioSpring is an innovative tool for interactive molecular modeling and simulation, designed to explore the dynamics of biological structures in real time. Using an augmented elastic network model, the BioSpring framework enables researchers to intuitively examine complex biomolecules, and it combines real-time feedback with the user's experience. This capability makes it ideal for initial analysis of molecular systems, protein-protein and protein-DNA docking, protein mechanics, and protein-membrane interactions. The multi-resolution modeling approach combines accuracy and efficiency, supporting user-driven analysis of molecular interactions, conformational flexibility, and structural mechanics. This framework improves upon traditional methods in terms of robustness, accessibility, and ease of use, while requiring only modest computational resources and enabling a fast turnaround time to obtain initial results. It provides insights into molecular function and dynamics that advance the field of structural biology. Source code, executables, and examples for the BioSpring simulation engine are available at https://biospring.mol3d.tech.
Source: Protein Science
DOI: 10.1002/pro.70130
Authors: Benoist Laurent, André Lanrezac, Hubert Santuz, Nicolas Ferey, Olivier Delalande, Marc Baaden
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Funder: Agence Nationale de la Recherche
Awards: Interactive Pharmacophore using Augmented Reality, Data mining, Visualization and Computational Modeling of Redox Signaling Networks, Multiscale Exploration of RNA poLymorphism for drug desIgN, Centre d'analyse de systèmes complexes dans les environnements complexes, Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.
OpenAlex ID: W4409567522