Year: 2025
Type: article
Abstract: Purpose The fluid shear stress (FSS) generated by fluid flow after stent implantation is an important factor affecting the osteogenic ability of scaffolds and the proliferation and differentiation of osteoblasts are also affected by FSS. When the bone injury occurs, the blood flow at the defect changes from laminar flow to turbulent flow. Consequently, it is essential to employ a numerical simulation method that accurately reflects the actual conditions to study and analyze the surface FSS experienced by scaffolds and cells, thereby enhancing the osteogenic properties of the scaffolds. Methods In this research, nine scaffolds with different structures and pore sizes were designed. The two-way fluid-structure interaction (FSI) method was used to evaluate scaffolds' internal flow field velocity and the surface FSS of scaffolds and cells. Results The results show that the velocity distribution of different scaffolds is basically the same. FSS on the scaffold surface and FSS on cell surface decreased with the increase of scaffold aperture. FSS accepted by cells was much larger than that received by scaffolds, and FSS was distributed in a stepped pattern on the cell surface. Conclusions Based on the FSS of the scaffold and cell surface, the triangle-600 and triangle-800 scaffolds have better osteogenic differentiation ability. This provides a more practical strategy for tissue engineering to design better scaffolds.
Institutions: Qilu University of Technology, Shandong Academy of Sciences
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4409567760