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Rapidly Fatal Metastatic Cholangiocarcinoma Associated With Metabolic Dysfunction–Associated Steatotic Liver Disease and Metabolic Syndrome: A Case Report Highlighting Emerging Risk Factors

Year: 2025

Type: article

Abstract: Cholangiocarcinoma (CCA), a rare biliary cancer, typically presents with nonspecific symptoms that hinder early diagnosis. Emerging metabolic risk factors are increasingly being recognized as contributors. We present the case of a 54-year-old woman with newly diagnosed metabolic dysfunction-associated steatotic liver disease and metabolic syndrome, who presented with acute abdominal pain and a subsequent liver biopsy-confirmed intrahepatic CCA. Despite chemotherapy and immunotherapy, rapid disease progression led to metastasis and systemic complications, resulting in death. This case highlights the aggressive nature of CCA and the importance of addressing modifiable metabolic risk factors to improve the outcomes.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001676

Authors: Joel Konlack, Akil Olliverrie, Nitin Pendyala, Joseph Yvan Bena, Guy Loic Nguefang, Nikisha Pandya, Christopher Chum

Institutions: Université de Yaoundé I, Texas Tech University Health Sciences Center

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409567956

FWCI:

Cites: 15

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Related to: 10