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Survival Outcomes of Preoperative Serum Biomarkers in Patients With Surgically Treated Intrahepatic Cholangiocarcinoma

Year: 2025

Type: article

Abstract: INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor, often diagnosed at advanced stages, with recurrence and metastasis significantly affecting survival. The combined prognostic value of biomarkers such as the Systemic Immune-Inflammation Index (SII), Fibrosis-4 (FIB-4), and Prognostic Nutritional Index (PNI) remains underexplored. METHODS: A retrospective analysis of 280 patients with ICC who underwent curative resection was performed. The prognostic significance of FIB-4, SII, and PNI for overall survival (OS) and disease-free survival (DFS) was assessed using clinical, pathological, and follow-up data. Statistical analysis included Cox regression and Kaplan-Meier survival curves. RESULTS: High PNI was significantly associated with better OS ( P = 0.014) and DFS ( P = 0.025). High FIB-4 levels correlated with worse OS ( P = 0.0076) and DFS ( P = 0.023). High SII was strongly associated with poor OS ( P < 0.0001) and DFS ( P = 0.00041). The combination of high SII, low PNI, and high FIB-4 was linked to significantly worse OS (hazard ratios = 2.633, P = 0.002) and DFS (hazard ratios = 2.475, P = 0.004). DISCUSSION: Preoperative serum biomarkers, including PNI, FIB-4, and SII, are significant independent prognostic factors for patients with ICC. Their combined use may help refine prognostic assessment and guide personalized treatment strategies.

Source: Clinical and Translational Gastroenterology

DOI: 10.14309/ctg.0000000000000845

Authors: Di Zeng, Shaofeng Wang, Nansheng Cheng, Geng Liu, Bei Li

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800