Year: 2025
Type: article
Abstract: A novel microdialysis method was utilised to evaluate the degree and range of drug dispersion from different formulations, including suspensions, emulsions, liposomes, and drug-protein complexes. The particles were sorted according to size using a microdialysis technique and then released, and the remaining medicines were examined simultaneously. To calculate the compound's initial flow, buffer solutions containing the drug (donor side) and drug-free buffer solutions (receiver side) were dialysed. The drug presence velocity on the receiver side was monitored. By using the micro dialysis approach, discriminatory drug release profiles were obtained for both the medication in solution and small-size suspension. This study examines the use of dialysis cartridges in developing in vitro evaluation methods for complex formulations.
Authors: Vaibhavi Patel, Jayrajsinh Sarvaiya, Piyush Patel, Pankit Bhavsar, Sheetal Budhdhdev, Jayshil Bhatt
Institutions: National Forensic Sciences University, Long Island University
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4409571700